Anti-SLC10A1 antibody (281-330 aa) (STJ96737)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human SLC10A1 at the amino acid range 281-330
General Information
| Short Description | Rabbit polyclonal anti-Hepatic sodium/bile acid cotransporter/bile acid cotransporter/taurocholate transport protein (281-330 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:20000IF 1:100-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC10A1 |
| Gene ID | 6554 |
| Uniprot ID | NTCP_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human SLC10A1 at the amino acid range 281-330 |
| Immunogen Region | 281-330 aa |
| Specificity | NTCP Polyclonal Antibody detects endogenous levels of NTCP protein. |
Additional Info
| Function | As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It is strictly dependent on the extracellular presence of sodium. It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate. Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation. (Microbial infection) Acts as an entry receptor for hepatitis B virus (HBV). The recognition for human SLC10A1/NTCP is highly specific. |
| Protein Name | Hepatic Sodium/Bile Acid CotransporterCell Growth-Inhibiting Gene 29 ProteinNa(+/Bile Acid CotransporterNa(+/Taurocholate Transport ProteinSodium/Taurocholate Cotransporting PolypeptideNtcpSolute Carrier Family 10 Member 1Slc10a1 |
| Database Links | Reactome: R-HSA-159418 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Hepatic Sodium/Bile Acid Cotransporter antibodyAnti-Cell Growth-Inhibiting Gene 29 Protein antibodyAnti-Na(+/Bile Acid Cotransporter antibodyAnti-Na(+/Taurocholate Transport Protein antibodyAnti-Sodium/Taurocholate Cotransporting Polypeptide antibodyAnti-Ntcp antibodyAnti-Solute Carrier Family 10 Member 1 antibodyAnti-Slc10a1 antibodyAnti-SLC10A1 antibodyAnti-NTCP antibodyAnti-GIG29 antibody |
Information sourced from Uniprot.org