| Tissue Specificity | Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon. |
| Post Translational Modifications | Phosphorylated by CSF1R. |
| Function | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. |
| Protein Name | Src-Like-Adapter 2Modulator Of Antigen Receptor SignalingMarsSrc-Like Adapter Protein 2Slap-2 |
| Database Links | Reactome: R-HSA-9706369 |
| Cellular Localisation | CytoplasmIsoform 1: Cell MembraneCytoplasmic VesicleLocalized To The Plasma Membrane And Intracellular VesiclesIncluding Late Endosomal VesiclesIsoform 2: CytoplasmMay Be Cytoplasmic And Is Not Localized To Membranes |
| Alternative Antibody Names | Anti-Src-Like-Adapter 2 antibodyAnti-Modulator Of Antigen Receptor Signaling antibodyAnti-Mars antibodyAnti-Src-Like Adapter Protein 2 antibodyAnti-Slap-2 antibodyAnti-SLA2 antibodyAnti-C20orf156 antibodyAnti-SLAP2 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and TXLNA knockout (KO) HeLa cells, using [KO Validated] TXLNA Rabbit polyclonal antibody (STJ11100765) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89702/358186/STJ11100765_1__45157.1713122500.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and TXLNA knockout (KO) HeLa cells, using [KO Validated] TXLNA Rabbit polyclonal antibody (STJ11100765) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
![Western blot analysis of lysates from wild type (WT) and SLC25A23 knockout (KO) 293T cells, using [KO Validated] SLC25A23 Rabbit polyclonal antibody (STJ11100753) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89691/358178/STJ11100753_1__66482.1713122487.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and SLC25A23 knockout (KO) 293T cells, using [KO Validated] SLC25A23 Rabbit polyclonal antibody (STJ11100753) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.")
