Anti-SLA2 antibody (1-160) (STJ114684)

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STJ114684
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLA2
Gene ID: 84174
Uniprot ID: SLAP2_HUMAN
Immunogen Region: 1-160
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SLA2 (NP_115590.1).
Immunogen Sequence: MGSLPSRRKSLPSPSLSSSV QGQGPVTMEAERSKATAVAL GSFPAGGPAELSLRLGEPLT IVSEDGDWWTVLSEVSGREY NIPSVHVAKVSHGWLYEGLS REKAEELLLLPGNPGGAFLI RESQTRRGSYSLSVRLSRPA SWDRIRHYRIHCLDNGWLYI
Tissue Specificity Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon.
Post Translational Modifications Phosphorylated by CSF1R.
Function Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Protein Name Src-Like-Adapter 2
Modulator Of Antigen Receptor Signaling
Mars
Src-Like Adapter Protein 2
Slap-2
Database Links Reactome: R-HSA-9706369
Cellular Localisation Cytoplasm
Isoform 1: Cell Membrane
Cytoplasmic Vesicle
Localized To The Plasma Membrane And Intracellular Vesicles
Including Late Endosomal Vesicles
Isoform 2: Cytoplasm
May Be Cytoplasmic And Is Not Localized To Membranes
Alternative Antibody Names Anti-Src-Like-Adapter 2 antibody
Anti-Modulator Of Antigen Receptor Signaling antibody
Anti-Mars antibody
Anti-Src-Like Adapter Protein 2 antibody
Anti-Slap-2 antibody
Anti-SLA2 antibody
Anti-C20orf156 antibody
Anti-SLAP2 antibody

Information sourced from Uniprot.org