| Post Translational Modifications | Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity. |
| Function | NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA, MRPL12 and the ATP synthase subunit ATP5PO. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription. Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation. Regulates hepatic lipogenesis. Uses NAD(+) substrate imported by SLC25A47, triggering downstream activation of PRKAA1/AMPK-alpha signaling cascade that ultimately downregulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating delactylation of proteins, such as CCNE2 and 'Lys-16' of histone H4 (H4K16la). |
| Protein Name | Nad-Dependent Protein Deacetylase Sirtuin-3 - MitochondrialHsirt3Nad-Dependent Protein Delactylase Sirtuin-3Regulatory Protein Sir2 Homolog 3Sir2-Like Protein 3 |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-9615017Reactome: R-HSA-9617629Reactome: R-HSA-9841251Reactome: R-HSA-9854311 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Nad-Dependent Protein Deacetylase Sirtuin-3 - Mitochondrial antibodyAnti-Hsirt3 antibodyAnti-Nad-Dependent Protein Delactylase Sirtuin-3 antibodyAnti-Regulatory Protein Sir2 Homolog 3 antibodyAnti-Sir2-Like Protein 3 antibodyAnti-SIRT3 antibodyAnti-SIR2L3 antibody |
Information sourced from Uniprot.org
