| Tissue Specificity | Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. |
| Post Translational Modifications | N-glycosylated. Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11. |
| Function | Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization. Receptor for THBS1. Interaction with THBS1 stimulates phosphorylation of SIRPA. In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1Shp Substrate 1Shps-1Brain Ig-Like Molecule With Tyrosine-Based Activation MotifsBitCd172 Antigen-Like Family Member AInhibitory Receptor Shps-1Macrophage Fusion ReceptorMyd-1 AntigenSignal-Regulatory Protein Alpha-1Sirp-Alpha-1Signal-Regulatory Protein Alpha-2Sirp-Alpha-2Signal-Regulatory Protein Alpha-3Sirp-Alpha-3P84Cd Antigen Cd172a |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-391160Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1 antibodyAnti-Shp Substrate 1 antibodyAnti-Shps-1 antibodyAnti-Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs antibodyAnti-Bit antibodyAnti-Cd172 Antigen-Like Family Member A antibodyAnti-Inhibitory Receptor Shps-1 antibodyAnti-Macrophage Fusion Receptor antibodyAnti-Myd-1 Antigen antibodyAnti-Signal-Regulatory Protein Alpha-1 antibodyAnti-Sirp-Alpha-1 antibodyAnti-Signal-Regulatory Protein Alpha-2 antibodyAnti-Sirp-Alpha-2 antibodyAnti-Signal-Regulatory Protein Alpha-3 antibodyAnti-Sirp-Alpha-3 antibodyAnti-P84 antibodyAnti-Cd Antigen Cd172a antibodyAnti-SIRPA antibodyAnti-BIT antibodyAnti-MFR antibodyAnti-MYD1 antibodyAnti-PTPNS1 antibodyAnti-SHPS1 antibodyAnti-SIRP antibody |
Information sourced from Uniprot.org
