| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SIN3B (1-160) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SIN3B |
| Gene ID: |
23309 |
| Uniprot ID: |
SIN3B_HUMAN |
| Immunogen Region: |
1-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SIN3B (NP_056075.1). |
| Immunogen Sequence: |
MAHAGGGSGGSGAGGPAGRG LSGARWGRSGSAGHEKLPVH VEDALTYLDQVKIRFGSDPA TYNGFLEIMKEFKSQSIDTP GVIRRVSQLFHEHPDLIVGF NAFLPLGYRIDIPKNGKLNI QSPLTSQENSHNHGDGAEDF KQQVPYKEDKPQVPLESDSV |
| Post Translational Modifications | Ubiquitinated by RNF220 that leads to proteasomal degradation. |
| Function | Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. |
| Protein Name | Paired Amphipathic Helix Protein Sin3bHistone Deacetylase Complex Subunit Sin3bTranscriptional Corepressor Sin3b |
| Database Links | Reactome: R-HSA-400206 O75182-1Reactome: R-HSA-427413Reactome: R-HSA-8936459Reactome: R-HSA-9707564 O75182-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paired Amphipathic Helix Protein Sin3b antibodyAnti-Histone Deacetylase Complex Subunit Sin3b antibodyAnti-Transcriptional Corepressor Sin3b antibodyAnti-SIN3B antibodyAnti-KIAA0700 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
