| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Serine/Threonine-Protein Kinase Sik3 (60-310) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SIK3 |
| Gene ID: |
23387 |
| Uniprot ID: |
SIK3_HUMAN |
| Immunogen Region: |
60-310 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 60-310 of human SIK3 (NP_079440.3). |
| Immunogen Sequence: |
PARIGYYEIDRTIGKGNFAV VKRATHLVTKAKVAIKIIDK TQLDEENLKKIFREVQIMKM LCHPHIIRLYQVMETERMIY LVTEYASGGEIFDHLVAHGR MAEKEARRKFKQIVTAVYFC HCRNIVHRDLKAENLLLDAN LNIKIADFGFSNLFTPGQLL KTWCGSPPYAAPELFEGKEY DGPKVDIWSLGVVLYVLVCG ALPFDGSTLQNLRARVLSGK FRIPFFMSTECEHLIRHML |
| Tissue Specificity | Expressed in chondrocytes. |
| Post Translational Modifications | Phosphorylated at Thr-221 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-221 is inhibited in response to PTHLH/PTHrP. Phosphorylated at Thr-469 and Ser-551 in response to cAMP signaling (Probable). |
| Function | Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus. |
| Protein Name | Serine/Threonine-Protein Kinase Sik3Salt-Inducible Kinase 3Sik-3Serine/Threonine-Protein Kinase Qsk |
| Cellular Localisation | CytoplasmLocates To Punctate Structures Within The Cytoplasm On Binding To Ywhaz |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Sik3 antibodyAnti-Salt-Inducible Kinase 3 antibodyAnti-Sik-3 antibodyAnti-Serine/Threonine-Protein Kinase Qsk antibodyAnti-SIK3 antibodyAnti-KIAA0999 antibodyAnti-QSK antibodyAnti-L19 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
