Anti-SIK2 antibody (STJA0010257)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human QIK/QSK
General Information
| Short Description | Rabbit polyclonal anti-Serine/threonine-protein kinase SIK2 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SIK2 |
| Gene ID | 23235 |
| Uniprot ID | SIK2_HUMAN |
| Immunogen | Synthesized peptide derived from human QIK/QSK |
| Specificity | This antibody detects endogenous levels of QIK/QSK at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylated at Thr-484 in response to insulin in adipocytes. Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6. |
| Function | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism. Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity. In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL. Also plays a role in thymic T-cell development. |
| Protein Name | Serine/Threonine-Protein Kinase Sik2Qin-Induced KinaseSalt-Inducible Kinase 2Sik-2Serine/Threonine-Protein Kinase Snf1-Like Kinase 2 |
| Database Links | |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Sik2 antibodyAnti-Qin-Induced Kinase antibodyAnti-Salt-Inducible Kinase 2 antibodyAnti-Sik-2 antibodyAnti-Serine/Threonine-Protein Kinase Snf1-Like Kinase 2 antibodyAnti-SIK2 antibodyAnti-KIAA0781 antibodyAnti-QIK antibodyAnti-SNF1LK2 antibody |
Information sourced from Uniprot.org