Anti-Siglec-8 antibody {ABflo® 594} (STJ11108602)

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STJ11108602
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Conjugation: ABflo® 594
Isotype: IgG
Formulation: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis) , pH 7.3.
Purification: Affinity purification
Dilution Range: FC, 5 Mu l per 10^6 cells in 100 Mu l volume
Storage Instruction: Store at 4°C for up to 1 year from the date of receipt. Do not freeze.
Gene Symbol: SIGLEC8
Gene ID: 27181
Uniprot ID: SIGL8_HUMAN
Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Tissue Specificity Expressed specifically on blood cells namely basophil, mast cells and eosinophils.
Function Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes.
Protein Name Sialic Acid-Binding Ig-Like Lectin 8
Siglec-8
Sialoadhesin Family Member 2
Saf-2
Database Links Reactome: R-HSA-198933
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Sialic Acid-Binding Ig-Like Lectin 8 antibody
Anti-Siglec-8 antibody
Anti-Sialoadhesin Family Member 2 antibody
Anti-Saf-2 antibody
Anti-SIGLEC8 antibody
Anti-SAF2 antibody

Information sourced from Uniprot.org

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