| Tissue Specificity | Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes. |
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). |
| Protein Name | Sialic Acid-Binding Ig-Like Lectin 7Siglec-7Adhesion Inhibitory Receptor Molecule 1Airm-1Cdw328D-SiglecQa79 Membrane ProteinP75Cd Antigen Cd328 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Sialic Acid-Binding Ig-Like Lectin 7 antibodyAnti-Siglec-7 antibodyAnti-Adhesion Inhibitory Receptor Molecule 1 antibodyAnti-Airm-1 antibodyAnti-Cdw328 antibodyAnti-D-Siglec antibodyAnti-Qa79 Membrane Protein antibodyAnti-P75 antibodyAnti-Cd Antigen Cd328 antibodyAnti-SIGLEC7 antibodyAnti-AIRM1 antibody |
Information sourced from Uniprot.org
