| Post Translational Modifications | Glycosylated. |
| Function | Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp. |
| Protein Name | Sid1 Transmembrane Family Member 2 |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinCell MembraneMainly Localizes To Lysosomes And Only Partly To The Plasma MembraneLysosomal Localization Is Required For Sidt2-Mediated Intracellular Degradation Of Endogenous Rna |
| Alternative Antibody Names | Anti-Sid1 Transmembrane Family Member 2 antibodyAnti-SIDT2 antibodyAnti-CGI-40 antibodyAnti-PSEC0072 antibodyAnti-UNQ685 antibodyAnti-PRO1325 antibody |
Information sourced from Uniprot.org
