| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation. |
| Function | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. |
| Protein Name | Sh2 Domain-Containing Adapter Protein B |
| Database Links | Reactome: R-HSA-4420097 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideAssociates With Membrane Lipid Rafts Upon Tcr Stimulation |
| Alternative Antibody Names | Anti-Sh2 Domain-Containing Adapter Protein B antibodyAnti-SHB antibody |
Information sourced from Uniprot.org
