| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5276RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SHB |
| Gene ID: | 6461 |
| Uniprot ID: | SHB_HUMAN |
| Immunogen Region: | 409-509 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 409-509 of human SHB (NP_003019.2). |
| Immunogen Sequence: | IWYHGAISRGDAENLLRLCK ECSYLVRNSQTSKHDYSLSL RSNQGFMHMKLAKTKEKYVL GQNSPPFDSVPEVIHYYTTR KLPIKGAEHLSLLYPVAVRT L |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation. |
| Function | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. |
| Protein Name | Sh2 Domain-Containing Adapter Protein B |
| Database Links | Reactome: R-HSA-4420097 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideAssociates With Membrane Lipid Rafts Upon Tcr Stimulation |
| Alternative Antibody Names | Anti-Sh2 Domain-Containing Adapter Protein B antibodyAnti-SHB antibody |
Information sourced from Uniprot.org
