| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SHB (300-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SHB |
| Gene ID: |
6461 |
| Uniprot ID: |
SHB_HUMAN |
| Immunogen Region: |
300-400 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 300-400 of human SHB (NP_003019.2). |
| Immunogen Sequence: |
PYEPEGQSVDSDSESTVSPR LRESKLPQDDDRPADEYDQP WEWNRVTIPALAAQFNGNEK RQSSPSPSRDRRRQLRAPGG GFKPIKHGSPEFCGILGERV D |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation. |
| Function | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. |
| Protein Name | Sh2 Domain-Containing Adapter Protein B |
| Database Links | Reactome: R-HSA-4420097 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideAssociates With Membrane Lipid Rafts Upon Tcr Stimulation |
| Alternative Antibody Names | Anti-Sh2 Domain-Containing Adapter Protein B antibodyAnti-SHB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
