Anti-SHANK3 antibody (1600-1650) {Biotin} (STJ502997)

SKU:
STJ502997-100

Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SHANK3 (1600-1650) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:150
IHC: 1:50-1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Shank3
Gene ID: 58234
Uniprot ID: SHAN3_MOUSE
Immunogen Region: 1600-1650
Immunogen: Synthetic peptide taken within amino acid region 1600-1650 on mouse SH3 and multiple ankyrin repeat domains protein 3.
Tissue Specificity In brain, highly expressed in striatum, thalamus, hippocampus and granule cells of the cerebellum.
Function Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.
Protein Name Sh3 And Multiple Ankyrin Repeat Domains Protein 3
Shank3
Proline-Rich Synapse-Associated Protein 2
Prosap2
Spank-2
Database Links Reactome: R-MMU-6794361
Reactome: -MMU-8853659
Cellular Localisation Cytoplasm
Synapse
Postsynaptic Density
Cell Projection
Dendritic Spine
In Neuronal Cells
Extends Into The Region Subjacent To The Postsynaptic Density (Psd)
Alternative Antibody Names Anti-Sh3 And Multiple Ankyrin Repeat Domains Protein 3 antibody
Anti-Shank3 antibody
Anti-Proline-Rich Synapse-Associated Protein 2 antibody
Anti-Prosap2 antibody
Anti-Spank-2 antibody
Anti-Shank3 antibody
Anti-Kiaa1650 antibody
Anti-Prosap2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance