Anti-SHANK1 antibody (STJA0007648)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SHANK1
General Information
| Short Description | Rabbit polyclonal anti-SH3 and multiple ankyrin repeat domains protein 1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SHANK1 |
| Gene ID | 50944 |
| Uniprot ID | SHAN1_HUMAN |
| Immunogen | Synthesized peptide derived from human SHANK1 |
| Specificity | This antibody detects endogenous levels of SHANK1 at Human, Mouse, Rat |
Additional Info
| Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Protein Name | Sh3 And Multiple Ankyrin Repeat Domains Protein 1Shank1Somatostatin Receptor-Interacting ProteinSstr-Interacting ProteinSstrip |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | CytoplasmPostsynaptic DensitySynapseColocalizes With Alpha-Latrotoxin Receptor 1 |
| Alternative Antibody Names | Anti-Sh3 And Multiple Ankyrin Repeat Domains Protein 1 antibodyAnti-Shank1 antibodyAnti-Somatostatin Receptor-Interacting Protein antibodyAnti-Sstr-Interacting Protein antibodyAnti-Sstrip antibodyAnti-SHANK1 antibody |
Information sourced from Uniprot.org