| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SH3 and multiple ankyrin repeat domains protein 1 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SHANK1 |
| Gene ID: | 50944 |
| Uniprot ID: | SHAN1_HUMAN |
| Specificity: | This antibody detects endogenous levels of SHANK1 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human SHANK1 |
| Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Protein Name | Sh3 And Multiple Ankyrin Repeat Domains Protein 1Shank1Somatostatin Receptor-Interacting ProteinSstr-Interacting ProteinSstrip |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | CytoplasmPostsynaptic DensitySynapseColocalizes With Alpha-Latrotoxin Receptor 1 |
| Alternative Antibody Names | Anti-Sh3 And Multiple Ankyrin Repeat Domains Protein 1 antibodyAnti-Shank1 antibodyAnti-Somatostatin Receptor-Interacting Protein antibodyAnti-Sstr-Interacting Protein antibodyAnti-Sstrip antibodyAnti-SHANK1 antibody |
Information sourced from Uniprot.org