| Tissue Specificity | Expressed only in brain (neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum). |
| Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function. |
| Protein Name | Sh3 And Multiple Ankyrin Repeat Domains Protein 1Shank1Gkap/Sapap-Interacting ProteinSpank-1Somatostatin Receptor-Interacting ProteinSstr-Interacting ProteinSstripSynamon |
| Database Links | Reactome: R-RNO-6794361 |
| Cellular Localisation | CytoplasmSynapsePostsynaptic DensityColocalizes With Alpha-Latrotoxin Receptor 1 |
| Alternative Antibody Names | Anti-Sh3 And Multiple Ankyrin Repeat Domains Protein 1 antibodyAnti-Shank1 antibodyAnti-Gkap/Sapap-Interacting Protein antibodyAnti-Spank-1 antibodyAnti-Somatostatin Receptor-Interacting Protein antibodyAnti-Sstr-Interacting Protein antibodyAnti-Sstrip antibodyAnti-Synamon antibodyAnti-Shank1 antibody |
Information sourced from Uniprot.org
