Anti-SH3RF2 antibody (STJA0009261)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SH3RF2
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase SH3RF2 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SH3RF2 |
| Gene ID | 153769 |
| Uniprot ID | SH3R2_HUMAN |
| Immunogen | Synthesized peptide derived from human SH3RF2 |
| Specificity | This antibody detects endogenous levels of SH3RF2 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Autoubiquitinated. |
| Function | Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation. Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity. |
| Protein Name | E3 Ubiquitin-Protein Ligase Sh3rf2Heart Protein Phosphatase 1-Binding ProteinHepp1Posh-Eliminating Ring ProteinProtein Phosphatase 1 Regulatory Subunit 39Ring Finger Protein 158Ring-Type E3 Ubiquitin Transferase Sh3rf2Sh3 Domain-Containing Ring Finger Protein 2 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Sh3rf2 antibodyAnti-Heart Protein Phosphatase 1-Binding Protein antibodyAnti-Hepp1 antibodyAnti-Posh-Eliminating Ring Protein antibodyAnti-Protein Phosphatase 1 Regulatory Subunit 39 antibodyAnti-Ring Finger Protein 158 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Sh3rf2 antibodyAnti-Sh3 Domain-Containing Ring Finger Protein 2 antibodyAnti-SH3RF2 antibodyAnti-POSH3 antibodyAnti-POSHER antibodyAnti-PPP1R39 antibodyAnti-RNF158 antibody |
Information sourced from Uniprot.org