| Tissue Specificity | Widely expressed. Highly expressed in testis. Expressed in lung, small intestine, breast, liver and placenta. Strongly overexpressed in 90% of breast cancers tested. |
| Post Translational Modifications | Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1. Phosphorylation by NEK2 is essential for chromosome congression in mitosis and for the proper attachment of spindle microtubule to the kinetochore. Phosphorylated by PLK1 and AUKRB. |
| Function | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. |
| Protein Name | Shugoshin 1Serologically Defined Breast Cancer Antigen Ny-Br-85Shugoshin-Like 1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreCytoplasmCytoskeletonSpindle PoleMicrotubule Organizing CenterCentrosomeLocalizes To The Inner Centromere Throughout Prophase Until Metaphase And Disappears At AnaphaseCentromeric Localization Requires The Presence Of Bub1 And The Interaction With Ppp2r1aColocalizes With Nek2 At The KinetochoreColocalizes With And Ss18l1 At The KinetochorePhosphorylation By Aukrb And The Presence Of Bub1 Are Required For Localization To The KinetochoreIsoform 1 Primarily Localizes To Kinetochores During G2 Phase And Mitotic ProphaseMetaphaseAnd Anaphase And Does Not Appear To Be Associated With Kinetochores During Late MitosisIsoform 3 Is Found At The Centrosome In Interphase And At Spindle Poles In Mitosis And Its Spindle Pole Localization Is Plk1 DependentIsoform 3 Does Not Localize To Kinetochores During Any Stages Of The Cell Cycle |
| Alternative Antibody Names | Anti-Shugoshin 1 antibodyAnti-Serologically Defined Breast Cancer Antigen Ny-Br-85 antibodyAnti-Shugoshin-Like 1 antibodyAnti-SGO1 antibodyAnti-SGOL1 antibody |
Information sourced from Uniprot.org
