| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SGMS1 (1-134) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SGMS1 |
| Gene ID: |
259230 |
| Uniprot ID: |
SMS1_HUMAN |
| Immunogen Region: |
1-134 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human SGMS1 (NP_671512.1). |
| Immunogen Sequence: |
MKEVVYWSPKKVADWLLENA MPEYCEPLEHFTGQDLINLT QEDFKKPPLCRVSSDNGQRL LDMIETLKMEHHLEAHKNGH ANGHLNIGVDIPTPDGSFSI KIKPNGMPNGYRKEMIKIPM PELERSQYPMEWGK |
| Tissue Specificity | Brain, heart, kidney, liver, muscle and stomach. |
| Function | Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Does not use free phosphorylcholine or CDP-choline as donor. Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1. |
| Protein Name | Phosphatidylcholine -Ceramide Cholinephosphotransferase 1Medulla Oblongata-Derived ProteinProtein MobSphingomyelin Synthase 1Transmembrane Protein 23 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Phosphatidylcholine -Ceramide Cholinephosphotransferase 1 antibodyAnti-Medulla Oblongata-Derived Protein antibodyAnti-Protein Mob antibodyAnti-Sphingomyelin Synthase 1 antibodyAnti-Transmembrane Protein 23 antibodyAnti-SGMS1 antibodyAnti-MOB antibodyAnti-SMS1 antibodyAnti-TMEM23 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
