Anti-SFTPA1/SFTPA2 antibody (102-115) (STJ72743)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-SFTPA1/SFTPA2 (102-115) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 30kDa band observed in Human Lung lysates (calculated MW of 27.7kDa according to NP_001087239.2). Recommended concentration: 0.01-0.03µg/ml.IHC: Paraffin embedded Human Lun |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SFTPA1 |
| Gene ID | 653509 |
| Uniprot ID | SFTA1_HUMAN |
| Accession Number | NP_005402.3; NP_001087239.2; NP_001158117.1; NP_001158118.1; NP_001092138.1 |
| Immunogen Region | 102-115 |
| Immunogen Sequence | HLDEELQATLHDFR |
| Specificity | This antibody is expected to recognize all the reported isoforms of A1 (NP_005402.3; NP_001087239.2; NP_001158117.1; NP_001158118.1) and A2 ( NP_001092138.1) , Reported variants represent identical protein: NP_001158116.1, NP_005402.3, NP_001158119.1 |
Additional Info
| Function | In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages. (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule. Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages. (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen. When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. |
| Protein Name | Pulmonary Surfactant-Associated Protein A1Psp-APspaSp-ASp-A135 Kda Pulmonary Surfactant-Associated ProteinAlveolar Proteinosis ProteinCollectin-4 |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-168179Reactome: R-HSA-391160Reactome: R-HSA-5683826Reactome: R-HSA-5686938Reactome: R-HSA-5688849Reactome: R-HSA-5688890 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixSurface Film |
| Alternative Antibody Names | Anti-Pulmonary Surfactant-Associated Protein A1 antibodyAnti-Psp-A antibodyAnti-Pspa antibodyAnti-Sp-A antibodyAnti-Sp-A1 antibodyAnti-35 Kda Pulmonary Surfactant-Associated Protein antibodyAnti-Alveolar Proteinosis Protein antibodyAnti-Collectin-4 antibodyAnti-SFTPA1 antibodyAnti-COLEC4 antibodyAnti-PSAP antibodyAnti-SFTP1 antibodyAnti-SFTPA antibodyAnti-SFTPA1B antibody |
Information sourced from Uniprot.org