| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Pulmonary surfactant-associated protein A1 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SFTPA1 |
| Gene ID: | 653509 |
| Uniprot ID: | SFTA1_HUMAN |
| Specificity: | SFTA1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Function | In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages. (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule. Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages. (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen. When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. |
| Protein Name | Pulmonary Surfactant-Associated Protein A1 Psp-A Pspa Sp-A Sp-A1 35 Kda Pulmonary Surfactant-Associated Protein Alveolar Proteinosis Protein Collectin-4 |
| Database Links | Reactome: R-HSA-166016 Reactome: R-HSA-168179 Reactome: R-HSA-391160 Reactome: R-HSA-5683826 Reactome: R-HSA-5686938 Reactome: R-HSA-5688849 Reactome: R-HSA-5688890 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix Surface Film |
| Alternative Antibody Names | Anti-Pulmonary Surfactant-Associated Protein A1 antibody Anti-Psp-A antibody Anti-Pspa antibody Anti-Sp-A antibody Anti-Sp-A1 antibody Anti-35 Kda Pulmonary Surfactant-Associated Protein antibody Anti-Alveolar Proteinosis Protein antibody Anti-Collectin-4 antibody Anti-SFTPA1 antibody Anti-COLEC4 antibody Anti-PSAP antibody Anti-SFTP1 antibody Anti-SFTPA antibody Anti-SFTPA1B antibody |
Information sourced from Uniprot.org