Anti-SETDB2 antibody (STJ191894)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Histone-lysine N-methyltransferase SETDB2 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SETDB2 |
| Gene ID | 83852 |
| Uniprot ID | SETB2_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | SETB2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. |
| Protein Name | Histone-Lysine N-Methyltransferase Setdb2Chronic Lymphocytic Leukemia Deletion Region Gene 8 ProteinLysine N-Methyltransferase 1fSet Domain Bifurcated 2 |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Setdb2 antibodyAnti-Chronic Lymphocytic Leukemia Deletion Region Gene 8 Protein antibodyAnti-Lysine N-Methyltransferase 1f antibodyAnti-Set Domain Bifurcated 2 antibodyAnti-SETDB2 antibodyAnti-C13orf4 antibodyAnti-CLLD8 antibodyAnti-KMT1F antibody |
Information sourced from Uniprot.org