• Immunohistochemistry of mouse tissue with Anti-SESN1 primary antibody (STJ502951) at 1:100 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 5X.

Anti-SESN1 antibody (1-50) (STJ502951)

SKU:
STJ502951-100

£441.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SESN1 (1-50) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SESN1
Gene ID: 27244
Uniprot ID: SESN1_HUMAN
Immunogen Region: 1-50
Immunogen: Synthetic peptide taken within amino acid region 1-50 on human SESN1 protein.
Tissue Specificity Widely expressed.
Function Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.
Protein Name Sestrin-1
P53-Regulated Protein Pa26
Database Links Reactome: R-HSA-5628897
Reactome: R-HSA-9639288
Reactome: R-HSA-9755511
Cellular Localisation Nucleus
Cytoplasm
Alternative Antibody Names Anti-Sestrin-1 antibody
Anti-P53-Regulated Protein Pa26 antibody
Anti-SESN1 antibody
Anti-PA26 antibody
Anti-SEST1 antibody

Information sourced from Uniprot.org

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