| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SERPINE1 (24-158) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SERPINE1 |
| Gene ID: |
5054 |
| Uniprot ID: |
PAI1_HUMAN |
| Immunogen Region: |
24-158 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-158 of human PAI-1/Serpin E1 (NP_000593.1). |
| Immunogen Sequence: |
VHHPPSYVAHLASDFGVRVF QQVAQASKDRNVVFSPYGVA SVLAMLQLTTGGETQQQIQA AMGFKIDDKGMAPALRHLYK ELMGPWNKDEISTTDAIFVQ RDLKLVQGFMPHFFRLFRST VKQVDFSEVERARFI |
| Tissue Specificity | Expressed in endothelial cells. Found in plasma, platelets, and hepatoma and fibrosarcoma cells. |
| Post Translational Modifications | Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond. |
| Function | Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis. |
| Protein Name | Plasminogen Activator Inhibitor 1PaiPai-1Endothelial Plasminogen Activator InhibitorSerpin E1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1368108Reactome: R-HSA-2173796Reactome: R-HSA-3000178Reactome: R-HSA-75205 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Plasminogen Activator Inhibitor 1 antibodyAnti-Pai antibodyAnti-Pai-1 antibodyAnti-Endothelial Plasminogen Activator Inhibitor antibodyAnti-Serpin E1 antibodyAnti-SERPINE1 antibodyAnti-PAI1 antibodyAnti-PLANH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
