| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Serotonin Receptor 3B/HTR3B (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 51kDa band observed in Human Brain (Cerebral Cortex, Hippocampus and Amygdala) lysates (calculated MW of 50.3kDa according to NP_006019.1). Recommended concentration: 1-3µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | HTR3B |
| Gene ID: | 9177 |
| Uniprot ID: | 5HT3B_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_006019.1 |
| Immunogen Sequence: | SNYLQTQDQTDQQE |
| Post Translational Modifications | N-glycosylation required for membrane localization. |
| Function | Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. |
| Protein Name | 5-Hydroxytryptamine Receptor 3b5-Ht3-B5-Ht3bSerotonin Receptor 3b |
| Database Links | Reactome: R-HSA-112314 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembranePresumably Retained Within The Endoplasmic Reticulum Unless Complexed With Htr3a |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 3b antibodyAnti-5-Ht3-B antibodyAnti-5-Ht3b antibodyAnti-Serotonin Receptor 3b antibodyAnti-HTR3B antibody |
Information sourced from Uniprot.org