| Tissue Specificity | Skeletal muscle, fast twitch muscle (type II) fibers. |
| Function | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. |
| Protein Name | Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1Serca1Sr Ca(2+-Atpase 1Calcium Pump 1Calcium-Transporting Atpase Sarcoplasmic Reticulum Type - Fast Twitch Skeletal Muscle IsoformEndoplasmic Reticulum Class 1/2 Ca(2+ Atpase |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-418359Reactome: R-HSA-5578775Reactome: R-HSA-936837 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinSarcoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 antibodyAnti-Serca1 antibodyAnti-Sr Ca(2+-Atpase 1 antibodyAnti-Calcium Pump 1 antibodyAnti-Calcium-Transporting Atpase Sarcoplasmic Reticulum Type - Fast Twitch Skeletal Muscle Isoform antibodyAnti-Endoplasmic Reticulum Class 1/2 Ca(2+ Atpase antibodyAnti-ATP2A1 antibody |
Information sourced from Uniprot.org
![Rat IgG2a Isotype Control [2A3] {Unconjugated} (STJA0022553)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/191269/412714/STJA0022553-SDS-PAGE-1__28012.1749230168.jpg?c=1 "Rat IgG2a Isotype Control [2A3] {Unconjugated} (STJA0022553)")