Anti-SEPTIN4 antibody (STJ193029)

SKU:
STJ193029

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Septin-4 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SEPTIN4
Gene ID: 5414
Uniprot ID: SEPT4_HUMAN
Specificity: SEPT4 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Phosphorylated by DYRK1A. Ubiquitinated by AREL1.
Function Filament-forming cytoskeletal GTPase (Probable). Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP. May also play a role in the regulation of cell fate in the intestine. Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis.via its interaction with XIAP. Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP. Plays an important role in male fertility and sperm motility. During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm. Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development. Required for dopaminergic metabolism in presynaptic autoreceptors.potentially via activity as a presynaptic scaffold protein. Isoform ARTS: Required for the induction of cell death mediated by TGF-beta and possibly by other apoptotic stimuli. Induces apoptosis through binding and inhibition of XIAP resulting in significant reduction in XIAP levels, leading to caspase activation and cell death. Mediates the interaction between BCL2 and XIAP, thereby positively regulating the ubiquitination and degradation of BCL2 and promoting apoptosis.
Protein Name Septin-4
Bradeion Beta
Brain Protein H5
Ce5b3 Beta
Cell Division Control-Related Protein 2
Hcdcrel-2
Peanut-Like Protein 2
Database Links Reactome: R-HSA-111457 O43236-6
Reactome: R-HSA-111469 O43236-6
Cellular Localisation Cytoplasm
Cell Projection
Cilium
Flagellum
Cytoplasmic Vesicle
Secretory Vesicle
Axon
Dendrite
Perikaryon
Synapse
In Platelets
Found In Areas Surrounding Alpha-Granules
Found In The Sperm Annulus
A Fibrous Ring Structure Connecting The Midpiece And The Principal Piece Of The Sperm Flagellum
Expressed And Colocalized With Slc6a3 And Snca In Axon Terminals
Especially At The Varicosities
Isoform Arts: Mitochondrion
Nucleus
While Predominantly Localized In The Mitochondria Under Resting Conditions
Translocates Into The Nucleus After Tgf-Beta Treatment And Apoptosis Induction
Alternative Antibody Names Anti-Septin-4 antibody
Anti-Bradeion Beta antibody
Anti-Brain Protein H5 antibody
Anti-Ce5b3 Beta antibody
Anti-Cell Division Control-Related Protein 2 antibody
Anti-Hcdcrel-2 antibody
Anti-Peanut-Like Protein 2 antibody
Anti-SEPTIN4 antibody
Anti-C17orf47 antibody
Anti-PNUTL2 antibody
Anti-SEP4 antibody
Anti-SEPT4 antibody
Anti-hucep-7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance