| Post Translational Modifications | Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity. Truncated SELENOK proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC2) complex, which recognizes the diglycine (Gly-Gly) at the C-terminus of truncated SELENOK proteins. |
| Function | Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes. |
| Protein Name | Selenoprotein KSelk |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinCell MembraneProbably Mainly Localized In The Er |
| Alternative Antibody Names | Anti-Selenoprotein K antibodyAnti-Selk antibodyAnti-SELENOK antibodyAnti-SELK antibodyAnti-HSPC030 antibodyAnti-HSPC297 antibody |
Information sourced from Uniprot.org
