Anti-SDHD antibody (50-150) (STJ118679)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SDHD (50-150) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SDHD |
| Gene ID | 6392 |
| Uniprot ID | DHSD_HUMAN |
| Immunogen Region | 50-150 |
| Immunogen Sequence | HLSPSHHSGSKAASLHWTSE RVVSVLLLGLLPAAYLNPCS AMDYSLAAALTLHGHWGLGQ VVTDYVHGDALQKAAKAGLL ALSALTFAGLCYFNYHDVGI C |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human SDHD (NP_002993.1). |
Additional Info
| Function | Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate. |
| Protein Name | Succinate Dehydrogenase Ubiquinone Cytochrome B Small Subunit - MitochondrialCybsCii-4Malate Dehydrogenase Quinone Cytochrome B Small SubunitQps3Succinate Dehydrogenase Complex Subunit DSuccinate-Ubiquinone Oxidoreductase Cytochrome B Small SubunitSuccinate-Ubiquinone Reductase Membrane Anchor Subunit |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-71403Reactome: R-HSA-9854311 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Succinate Dehydrogenase Ubiquinone Cytochrome B Small Subunit - Mitochondrial antibodyAnti-Cybs antibodyAnti-Cii-4 antibodyAnti-Malate Dehydrogenase Quinone Cytochrome B Small Subunit antibodyAnti-Qps3 antibodyAnti-Succinate Dehydrogenase Complex Subunit D antibodyAnti-Succinate-Ubiquinone Oxidoreductase Cytochrome B Small Subunit antibodyAnti-Succinate-Ubiquinone Reductase Membrane Anchor Subunit antibodyAnti-SDHD antibodyAnti-SDH4 antibody |
Information sourced from Uniprot.org