| Post Translational Modifications | Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation. Acetylated. Deacetylated by SIRT3. |
| Function | Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate. Can act as a tumor suppressor. |
| Protein Name | Succinate Dehydrogenase Ubiquinone Flavoprotein Subunit - MitochondrialFlavoprotein Subunit Of Complex IiFpMalate Dehydrogenase Quinone Flavoprotein Subunit |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-71403Reactome: R-HSA-9854311 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix Side |
| Alternative Antibody Names | Anti-Succinate Dehydrogenase Ubiquinone Flavoprotein Subunit - Mitochondrial antibodyAnti-Flavoprotein Subunit Of Complex Ii antibodyAnti-Fp antibodyAnti-Malate Dehydrogenase Quinone Flavoprotein Subunit antibodyAnti-SDHA antibodyAnti-SDH2 antibodyAnti-SDHF antibody |
Information sourced from Uniprot.org
