| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Syndecan-4 (145-194 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SDC4 |
| Gene ID: | 6385 |
| Uniprot ID: | SDC4_HUMAN |
| Immunogen Region: | 145-194 aa |
| Specificity: | Syndecan-4 Polyclonal Antibody detects endogenous levels of Syndecan-4 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Syndecan4 at the amino acid range 145-194 |
| Post Translational Modifications | Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. O-glycosylated.contains both chondroitin sulfate and heparan sulfate. Ser-39, Ser-61 and Ser-63 can all be modified by either chondroitin sulfate or heparan sulfate, and the protein exists in forms that contain only chondroitin sulfate, only heparan sulfate and both chondroitin sulfate and heparan sulfate. |
| Function | Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP. |
| Protein Name | Syndecan-4 Synd4 Amphiglycan Ryudocan Core Protein |
| Database Links | Reactome: R-HSA-1971475 Reactome: R-HSA-2022928 Reactome: R-HSA-2024096 Reactome: R-HSA-202733 Reactome: R-HSA-3000170 Reactome: R-HSA-3560783 Reactome: R-HSA-3560801 Reactome: R-HSA-3656237 Reactome: R-HSA-3656253 Reactome: R-HSA-4420332 Reactome: R-HSA-9694614 Reactome: R-HSA-975634 Reactome: R-HSA-9820960 Reactome: R-HSA-9833110 |
| Cellular Localisation | Isoform 1: Membrane Single-Pass Type I Membrane Protein Secreted Shedding Of The Ectodomain Produces A Soluble Form Isoform 2: Secreted |
| Alternative Antibody Names | Anti-Syndecan-4 antibody Anti-Synd4 antibody Anti-Amphiglycan antibody Anti-Ryudocan Core Protein antibody Anti-SDC4 antibody |
Information sourced from Uniprot.org