| Tissue Specificity | Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level). |
| Post Translational Modifications | Ubiquitinated.targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and degraded. Palmitoylated. Could be depalmitoylated by LYPLA1 and/or LYPLA2. Palmitoylation of SCRIB by ZDHHC7 is required for its localization to cell-cell junctions, function in the establishement of epithelial cell polarity and the regulation of downstream signaling pathways important for epithelial cell differentiation. |
| Function | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization. Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production. Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May regulate cell invasion via MAPK-mediated cell migration and adhesion. May play a role in exocytosis and in the targeting of synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity. |
| Protein Name | Protein Scribble HomologScribbleHscribProtein Lap4 |
| Database Links | Reactome: R-HSA-4608870Reactome: R-HSA-9013148Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9696264Reactome: R-HSA-9696270 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCell JunctionAdherens JunctionCell ProjectionLamellipodiumCytoplasmPostsynapsePresynapseTargeting To Cell-Cell Junctions Which Is Cdh1-Dependent Is Required For The Pro-Apoptotic ActivityIn A Subset Of Cd4+ T-CellsColocalizes With Crtam At The Immunological Synapse During The Late Phase Of T-Cell ActivationLocalized To Small Puncta Throughout The Cytoplasm And Cell Membrane When In The Presence Of Snail1Localized Along The Length Of Perinuclear Emanating Vimentin Bundles And At Vimentin-Positive Fibrils At The Cell PeripheryLocalized To The Lateral Plasma Membrane During The Establishment And Maturation Of Cell-Cell Contacts |
| Alternative Antibody Names | Anti-Protein Scribble Homolog antibodyAnti-Scribble antibodyAnti-Hscrib antibodyAnti-Protein Lap4 antibodyAnti-SCRIB antibodyAnti-CRIB1 antibodyAnti-KIAA0147 antibodyAnti-LAP4 antibodyAnti-SCRB1 antibodyAnti-VARTUL antibody |
Information sourced from Uniprot.org
