| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Secretogranin-3 (21-70 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:100-300 ELISA 1:20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SCG3 |
| Gene ID: | 29106 |
| Uniprot ID: | SCG3_HUMAN |
| Immunogen Region: | 21-70 aa |
| Specificity: | Sg III Polyclonal Antibody detects endogenous levels of Sg III protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the N-terminal region of human SCG3 at the amino acid range 21-70 |
| Post Translational Modifications | O-glycosylated. |
| Function | Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway. |
| Protein Name | Secretogranin-3 Secretogranin Iii Sgiii |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-381426 Reactome: R-HSA-8957275 |
| Cellular Localisation | Cytoplasmic Vesicle Secretory Vesicle Secretory Vesicle Membrane Peripheral Membrane Protein Secreted Associated With The Secretory Granule Membrane Through Direct Binding To Cholesterol-Enriched Lipid Rafts |
| Alternative Antibody Names | Anti-Secretogranin-3 antibody Anti-Secretogranin Iii antibody Anti-Sgiii antibody Anti-SCG3 antibody Anti-UNQ2502 antibody Anti-PRO5990 antibody |
Information sourced from Uniprot.org