| Tissue Specificity | Detected in urine (at protein level). Expressed in brain, heart, kidney, liver and skeletal muscle. |
| Post Translational Modifications | O-glycosylated. |
| Function | Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway. |
| Protein Name | Secretogranin-3Secretogranin IiiSgiii |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSecretory Vesicle MembranePeripheral Membrane ProteinSecretedAssociated With The Secretory Granule Membrane Through Direct Binding To Cholesterol-Enriched Lipid Rafts |
| Alternative Antibody Names | Anti-Secretogranin-3 antibodyAnti-Secretogranin Iii antibodyAnti-Sgiii antibodyAnti-SCG3 antibodyAnti-UNQ2502 antibodyAnti-PRO5990 antibody |
Information sourced from Uniprot.org
