| Function | Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough. |
| Protein Name | Sr-Related And Ctd-Associated Factor 4Ctd-Binding Sr-Like Protein Ra4Splicing Factor - Arginine/Serine-Rich 15 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Sr-Related And Ctd-Associated Factor 4 antibodyAnti-Ctd-Binding Sr-Like Protein Ra4 antibodyAnti-Splicing Factor - Arginine/Serine-Rich 15 antibodyAnti-SCAF4 antibodyAnti-KIAA1172 antibodyAnti-SFRS15 antibody |
Information sourced from Uniprot.org
