| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-S-arrestin (210-290 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SAG |
| Gene ID: | 6295 |
| Uniprot ID: | ARRS_HUMAN |
| Immunogen Region: | 210-290 aa |
| Specificity: | ARRS Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 210-290 |
| Function | Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells. |
| Protein Name | S-Arrestin48 Kda ProteinRetinal S-AntigenS-AgRod Photoreceptor Arrestin |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-2514859 |
| Cellular Localisation | Cell ProjectionCiliumPhotoreceptor Outer SegmentMembranePeripheral Membrane ProteinHighly Expressed In Photoreceptor Outer Segments In Light-Exposed RetinaEvenly Distributed Throughout Rod Photoreceptor Cells In Dark-Adapted RetinaPredominantly Dectected At The Proximal Region Of Photoreceptor Outer SegmentsNear Disk Membranes |
| Alternative Antibody Names | Anti-S-Arrestin antibodyAnti-48 Kda Protein antibodyAnti-Retinal S-Antigen antibodyAnti-S-Ag antibodyAnti-Rod Photoreceptor Arrestin antibodyAnti-SAG antibody |
Information sourced from Uniprot.org