| Tissue Specificity | Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines. |
| Post Translational Modifications | Sumoylated by PIAS1 with SUMO1 and SUMO2/3, desumoylated by SENP1. Sumoylation is required for transcriptional repressor activity. |
| Function | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Thereby acts as a negative regulator of cell proliferation. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter. |
| Protein Name | Scaffold Attachment Factor B1Saf-BSaf-B1Hsp27 Estrogen Response Element-Tata Box-Binding ProteinHsp27 Ere-Tata-Binding Protein |
| Database Links | Reactome: R-HSA-3899300 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Scaffold Attachment Factor B1 antibodyAnti-Saf-B antibodyAnti-Saf-B1 antibodyAnti-Hsp27 Estrogen Response Element-Tata Box-Binding Protein antibodyAnti-Hsp27 Ere-Tata-Binding Protein antibodyAnti-SAFB antibodyAnti-HAP antibodyAnti-HET antibodyAnti-SAFB1 antibody |
Information sourced from Uniprot.org
