Anti-S100A1 antibody (STJ197337)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant Protein of S100
General Information
| Short Description | Rabbit polyclonal anti-Protein S100-A1 for use in WB, IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | S100A1 |
| Gene ID | 6271 |
| Uniprot ID | S10A1_HUMAN |
| Immunogen | Recombinant Protein of S100 |
| Specificity | The antibody detects endogenous S100 protein |
Additional Info
| Post Translational Modifications | Glutathionylated.glutathionylation increases affinity to calcium about 10-fold. |
| Function | Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole. |
| Protein Name | Protein S100-A1S-100 Protein Alpha ChainS-100 Protein Subunit AlphaS100 Calcium-Binding Protein A1 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-166058Reactome: R-HSA-5602498Reactome: R-HSA-5603041Reactome: R-HSA-5686938 |
| Cellular Localisation | CytoplasmSarcoplasmic ReticulumMitochondrion |
| Alternative Antibody Names | Anti-Protein S100-A1 antibodyAnti-S-100 Protein Alpha Chain antibodyAnti-S-100 Protein Subunit Alpha antibodyAnti-S100 Calcium-Binding Protein A1 antibodyAnti-S100A1 antibodyAnti-S100A antibody |
Information sourced from Uniprot.org