| Tissue Specificity | Observed in all the tissues examined. |
| Post Translational Modifications | Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation. |
| Function | May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. |
| Protein Name | Tyrosine-Protein Kinase Ryk |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-4086400 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinNucleusCytoplasmIn Cells That Have Undergone Neuronal DifferentiationThe C-Terminal Cleaved Part Is Translocated From The Cytoplasm To The Nucleus |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Ryk antibodyAnti-RYK antibodyAnti-JTK5A antibody |
Information sourced from Uniprot.org
