Anti-RUNX1T1 antibody (250-403) (STJ111109)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RUNX1T1 (250-403) antibody for use in WB and ELISA in rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RUNX1T1 |
| Gene ID | 862 |
| Uniprot ID | MTG8_HUMAN |
| Immunogen Region | 250-403 |
| Immunogen Sequence | ENGFDREPLHSEHPSKRPCT ISPGQRYSPNNGLSYQPNGL PHPTPPPPQHYRLDDMAIAH HYRDSYRHPSHRDLRDRNRP MGLHGTRQEEMIDHRLTDRE WAEEWKHLDHLLNCIMDMVE KTRRSLTVLRRCQEADREEL NYWIRRYSDAEDLK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 250-403 of human RUNX1T1 (NP_783552.1). |
Additional Info
| Tissue Specificity | Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary. |
| Function | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12. Acts as a negative regulator of adipogenesis. The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal. |
| Protein Name | Protein Cbfa2t1Cyclin-D-Related ProteinEight Twenty One ProteinProtein EtoProtein Mtg8Zinc Finger Mynd Domain-Containing Protein 2 |
| Database Links | |
| Cellular Localisation | NucleusColocalizes With Atn1 In Discrete Nuclear Dots |
| Alternative Antibody Names | Anti-Protein Cbfa2t1 antibodyAnti-Cyclin-D-Related Protein antibodyAnti-Eight Twenty One Protein antibodyAnti-Protein Eto antibodyAnti-Protein Mtg8 antibodyAnti-Zinc Finger Mynd Domain-Containing Protein 2 antibodyAnti-RUNX1T1 antibodyAnti-AML1T1 antibodyAnti-CBFA2T1 antibodyAnti-CDR antibodyAnti-ETO antibodyAnti-MTG8 antibodyAnti-ZMYND2 antibody |
Information sourced from Uniprot.org