Anti-RTN4IP1 antibody (282-332 aa) (STJ195183)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human RT4I1 at the amino acid range 282-332
General Information
| Short Description | Rabbit polyclonal anti-Reticulon-4-interacting protein 1, mitochondrial (282-332 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RTN4IP1 |
| Gene ID | 84816 |
| Uniprot ID | RT4I1_HUMAN |
| Immunogen | Synthesized peptide derived from the human RT4I1 at the amino acid range 282-332 |
| Immunogen Region | 282-332 aa |
| Specificity | This antibody detects endogenous levels of RT4I1 at Human/Mouse |
Additional Info
| Function | NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway. Required for the O-methyltransferase activity of COQ3. Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro. However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo. May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury. |
| Protein Name | Nad(Ph Oxidoreductase Rtn4ip1 - MitochondrialNogo-Interacting Mitochondrial ProteinReticulon-4-Interacting Protein 1 |
| Database Links | |
| Cellular Localisation | Mitochondrion MatrixMitochondrion Outer MembraneMainly Localizes To The Mitochondrial MatrixAlso Colocalizes With The Endoplasmic Reticulum Hspa5 At Spots Corresponding To Contacts With Mitochondria |
| Alternative Antibody Names | Anti-Nad(Ph Oxidoreductase Rtn4ip1 - Mitochondrial antibodyAnti-Nogo-Interacting Mitochondrial Protein antibodyAnti-Reticulon-4-Interacting Protein 1 antibodyAnti-RTN4IP1 antibodyAnti-NIMP antibody |
Information sourced from Uniprot.org