| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RTN1 (80-340) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RTN1 |
| Gene ID: |
6252 |
| Uniprot ID: |
RTN1_HUMAN |
| Immunogen Region: |
80-340 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human RTN1 (NP_066959.1). |
| Immunogen Sequence: |
TGVAGVSSAMDHTFSTTSKD GEGSCYTSLISDICYPPQED STYFTGILQKENGHVTISES PEELGTPGPSLPDVPGIESR GLFSSDSGIEMTPAESTEVN KILADPLDQMKAEAYKYIDI TRPEEVKHQEQHHPELEDKD LDFKNKDTDISIKPEGVREP DKPAPVEGKIIKDHLLEEST FAPYIDDLSEEQRRAPQITT PVKITLTEIEPSVETTTQEK TPEKQDICLKPSPDTVPTV |
| Tissue Specificity | Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation. |
| Post Translational Modifications | Isoforms RTN1-A and RTN1-B are phosphorylated. |
| Function | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. |
| Protein Name | Reticulon-1Neuroendocrine-Specific Protein |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Reticulon-1 antibodyAnti-Neuroendocrine-Specific Protein antibodyAnti-RTN1 antibodyAnti-NSP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
