| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RTN1 |
| Gene ID: | 6252 |
| Uniprot ID: | RTN1_HUMAN |
| Immunogen Region: | 80-340 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human RTN1 (NP_066959.1). |
| Immunogen Sequence: | TGVAGVSSAMDHTFSTTSKD GEGSCYTSLISDICYPPQED STYFTGILQKENGHVTISES PEELGTPGPSLPDVPGIESR GLFSSDSGIEMTPAESTEVN KILADPLDQMKAEAYKYIDI TRPEEVKHQEQHHPELEDKD LDFKNKDTDISIKPEGVREP DKPAPVEGKIIKDHLLEEST FAPYIDDLSEEQRRAPQITT PVKITLTEIEPSVETTTQEK TPEKQDICLKPSPDTVPTV |
| Tissue Specificity | Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation. |
| Post Translational Modifications | Isoforms RTN1-A and RTN1-B are phosphorylated. |
| Function | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. |
| Protein Name | Reticulon-1Neuroendocrine-Specific Protein |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Reticulon-1 antibodyAnti-Neuroendocrine-Specific Protein antibodyAnti-RTN1 antibodyAnti-NSP antibody |
Information sourced from Uniprot.org