• Western blot analysis of lysates from mouse lung, using RTN1 Rabbit polyclonal antibody (STJ118855) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 5 min.

Anti-RTN1 antibody (80-340) (STJ118855)

SKU:
STJ118855

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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RTN1 (80-340) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RTN1
Gene ID: 6252
Uniprot ID: RTN1_HUMAN
Immunogen Region: 80-340
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human RTN1 (NP_066959.1).
Immunogen Sequence: TGVAGVSSAMDHTFSTTSKD GEGSCYTSLISDICYPPQED STYFTGILQKENGHVTISES PEELGTPGPSLPDVPGIESR GLFSSDSGIEMTPAESTEVN KILADPLDQMKAEAYKYIDI TRPEEVKHQEQHHPELEDKD LDFKNKDTDISIKPEGVREP DKPAPVEGKIIKDHLLEEST FAPYIDDLSEEQRRAPQITT PVKITLTEIEPSVETTTQEK TPEKQDICLKPSPDTVPTV
Tissue Specificity Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation.
Post Translational Modifications Isoforms RTN1-A and RTN1-B are phosphorylated.
Function Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
Protein Name Reticulon-1
Neuroendocrine-Specific Protein
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Membrane
Alternative Antibody Names Anti-Reticulon-1 antibody
Anti-Neuroendocrine-Specific Protein antibody
Anti-RTN1 antibody
Anti-NSP antibody

Information sourced from Uniprot.org

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