Anti-RRAD antibody (41-90 aa) (STJ95321)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RAD at the amino acid range 41-90
General Information
| Short Description | Rabbit polyclonal anti-GTP-binding protein RAD (41-90 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RRAD |
| Gene ID | 6236 |
| Uniprot ID | RAD_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RAD at the amino acid range 41-90 |
| Immunogen Region | 41-90 aa |
| Specificity | Rad GTPase Polyclonal Antibody detects endogenous levels of Rad GTPase protein. |
Additional Info
| Function | May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. |
| Protein Name | Gtp-Binding Protein RadRad1Ras Associated With Diabetes |
| Database Links | Reactome: R-HSA-9031628 |
| Cellular Localisation | Cell Membrane |
| Alternative Antibody Names | Anti-Gtp-Binding Protein Rad antibodyAnti-Rad1 antibodyAnti-Ras Associated With Diabetes antibodyAnti-RRAD antibodyAnti-RAD antibody |
Information sourced from Uniprot.org