Anti-RPS6KA2 antibody (C-Term) (STJA0003771)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.
General Information
| Short Description | Rabbit polyclonal anti-Ribosomal S6 kinase 2 (C-Term) for use in WB in Human, Bovine, Canine, Chicken, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Bovine/Canine/Chicken/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range | WB 1:1000 |
| Formulation | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Rps6ka2 |
| Gene ID | 20112 |
| Uniprot ID | KS6A2_MOUSE |
| Immunogen | Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH. |
| Immunogen Region | C-Term |
Additional Info
| Post Translational Modifications | Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1. N-terminal myristoylation results in an activated kinase in the absence of added growth factors. |
| Function | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. |
| Protein Name | Ribosomal Protein S6 Kinase Alpha-2S6k-Alpha-290 Kda Ribosomal Protein S6 Kinase 2P90-Rsk 2P90rsk2Map Kinase-Activated Protein Kinase 1cMapk-Activated Protein Kinase 1cMapkap Kinase 1cMapkapk-1cProtein-Tyrosine Kinase Mpk-9Ribosomal S6 Kinase 3Rsk-3Pp90rsk3 |
| Database Links | Reactome: R-MMU-198753Reactome: -MMU-199920Reactome: -MMU-2559582Reactome: -MMU-442742Reactome: -MMU-444257Reactome: -MMU-881907 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Ribosomal Protein S6 Kinase Alpha-2 antibodyAnti-S6k-Alpha-2 antibodyAnti-90 Kda Ribosomal Protein S6 Kinase 2 antibodyAnti-P90-Rsk 2 antibodyAnti-P90rsk2 antibodyAnti-Map Kinase-Activated Protein Kinase 1c antibodyAnti-Mapk-Activated Protein Kinase 1c antibodyAnti-Mapkap Kinase 1c antibodyAnti-Mapkapk-1c antibodyAnti-Protein-Tyrosine Kinase Mpk-9 antibodyAnti-Ribosomal S6 Kinase 3 antibodyAnti-Rsk-3 antibodyAnti-Pp90rsk3 antibodyAnti-Rps6ka2 antibodyAnti-Mapkapk1c antibodyAnti-Rsk3 antibody |
Information sourced from Uniprot.org