• Immunofluorescence analysis of MCF-7 cells using RPL11 antibody (STJ115503). Blue: DAPI for nuclear staining.

Anti-RPL11 antibody (1-177) (STJ115503)

SKU:
STJ115503

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Host: Rabbit
Applications: IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RPL11 (1-177) is suitable for use in Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RPL11
Gene ID: 6135
Uniprot ID: RL11_HUMAN
Immunogen Region: 1-177
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-177 of human RPL11 (NP_001186731.1).
Immunogen Sequence: MADQGEKENPMRELRIRKLC LNICVGESGDRLTRAAKVLE QLTGQTPVFSKARYTVRSFG IRRNEKIAVHCTVRGAKAEE ILEKGLKVREYELRKNNFSD TGNFGFGIQEHIDLGIKYDP SIGIYGLDFYVVLGRPGFSI ADKKRRTGCIGAKHRISKEE AMRWFQQKYDGIILPGK
Function Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Promotes nucleolar location of PML.
Protein Name Large Ribosomal Subunit Protein Ul5
60s Ribosomal Protein L11
Cll-Associated Antigen Kw-12
Database Links Reactome: R-HSA-156827
Reactome: R-HSA-156902
Reactome: R-HSA-1799339
Reactome: R-HSA-192823
Reactome: R-HSA-2408557
Reactome: R-HSA-6791226
Reactome: R-HSA-72689
Reactome: R-HSA-72706
Reactome: R-HSA-72764
Reactome: R-HSA-9010553
Reactome: R-HSA-9633012
Reactome: R-HSA-975956
Reactome: R-HSA-975957
Cellular Localisation Nucleus
Nucleolus
Cytoplasm
Alternative Antibody Names Anti-Large Ribosomal Subunit Protein Ul5 antibody
Anti-60s Ribosomal Protein L11 antibody
Anti-Cll-Associated Antigen Kw-12 antibody
Anti-RPL11 antibody

Information sourced from Uniprot.org

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