Anti-RPH3A antibody (203-252 aa) (STJ95315)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Rabphilin 3A at the amino acid range 203-252
General Information
| Short Description | Rabbit polyclonal anti-Rabphilin-3A (203-252 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RPH3A |
| Gene ID | 22895 |
| Uniprot ID | RP3A_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Rabphilin 3A at the amino acid range 203-252 |
| Immunogen Region | 203-252 aa |
| Specificity | Rabphilin-3A Polyclonal Antibody detects endogenous levels of Rabphilin-3A protein. |
Additional Info
| Function | Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone. |
| Protein Name | Rabphilin-3aExophilin-1 |
| Database Links | |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneCell ProjectionDendritic SpinePostsynaptic Cell MembraneMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Rabphilin-3a antibodyAnti-Exophilin-1 antibodyAnti-RPH3A antibodyAnti-KIAA0985 antibody |
Information sourced from Uniprot.org