Anti-RPGRIP1 antibody (1091-1286) (STJ11105383)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal X-Linked Retinitis Pigmentosa Gtpase Regulator-Interacting Protein 1 (1091-1286) antibody for use in IF, ICC and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RPGRIP1 |
| Gene ID | 57096 |
| Uniprot ID | RPGR1_HUMAN |
| Immunogen Region | 1091-1286 |
| Immunogen Sequence | SEAQTTDSDDVIVPPMSQKY PKADSEKMCIEIVSLAFYPE AEVMSDENIKQVYVEYKFYD LPLSETETPVSLRKPRAGEE IHFHFSKVIDLDPQEQQGRR RFLFDMLNGQDPDQGHLKFT VVSDPLDEEKKECEEVGYAY LQLWQILESGRDILEQELDI VSPEDLATPIGRLKVSLQAA AVLHAIYKEMTEDLFS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1091-1286 of human RPGRIP1 (NP_065099.3). |
Additional Info
| Tissue Specificity | Strong expression in retina, with weaker expression in testis. Expressed in other neurons such as amacrine cells. Colocalizes with RGPR in the outer segment of rod photoreceptors and cone outer segments. |
| Function | May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells. |
| Protein Name | X-Linked Retinitis Pigmentosa Gtpase Regulator-Interacting Protein 1Rpgr-Interacting Protein 1 |
| Database Links | |
| Cellular Localisation | Cell ProjectionCiliumSituated Between The Axonemal Microtubules And The Plasma MembraneIn The Retinal Photoreceptor Cell LayerLocalizes At The Connecting CiliumA Thin Bridge Linking The Cell Body And The Light-Sensing Outer SegmentColocalizes With Rgpr In The Photoreceptor Connecting Cilium |
| Alternative Antibody Names | Anti-X-Linked Retinitis Pigmentosa Gtpase Regulator-Interacting Protein 1 antibodyAnti-Rpgr-Interacting Protein 1 antibodyAnti-RPGRIP1 antibody |
Information sourced from Uniprot.org