| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
RPA4 |
| Gene ID: |
29935 |
| Uniprot ID: |
RFA4_HUMAN |
| Immunogen Region: |
1-230 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human RPA4 (NP_037479.1). |
| Immunogen Sequence: |
MSKSGFGSYGSISAADGASG GSDQLCERDATPAIKTQRPK VRIQDVVPCNVNQLLSSTVF DPVFKVRGIIVSQVSIVGVI RGAEKASNHICYKIDDMTAK PIEARQWFGREKVKQVTPLS VGVYVKVFGILKCPTGTKSL EVLKIHVLEDMNEFTVHILE TVNAHMMLDKARRDTTVESV PVSPSEVNDAGDNDESHRNF IQDEVLRLIHECPHQEGKSI HELRAQLCDL |
| Tissue Specificity | Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels. |
| Function | As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. |
| Protein Name | Replication Protein A 30 Kda SubunitRp-A P30Replication Factor A Protein 4Rf-A Protein 4 |
| Database Links | Reactome: R-HSA-68962 |
| Cellular Localisation | NucleusLocalizes To Dna Repair Foci After Dna Damage |
| Alternative Antibody Names | Anti-Replication Protein A 30 Kda Subunit antibodyAnti-Rp-A P30 antibodyAnti-Replication Factor A Protein 4 antibodyAnti-Rf-A Protein 4 antibodyAnti-RPA4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
